Expanded cells in monoclonal TCR- /CD4 /NKa /CD8 / dim T-LGL lymphocytosis recognize hCMV antigens
نویسندگان
چکیده
1Servicio de Citometría & Departamento de Medicina, Universidad de Salamanca, Salamanca, Spain; 2Instituto de Biología Molecular y Celular del Cáncer, Centro de Investigación del Cáncer/Universidad de Salamanca/Consejo Superior Investigaciones Cientificas, Salamanca, Spain; 3Servicio de Análisis Clínicos, Hospital Universitario Virgen de las Nieves, Granada, Spain; 4Unidad de Investigación, Instituto Estudios Ciencias de la Salaud de Castilla y Leon-Hospital Universitario de Salamanca, Salamanca, Spain; 5Servicio de Hematología, Hospital Universitario Virgen de las Nieves, Granada, Spain; 6Servicio de Microbiología, Hospital Universitario de Salamanca, Salamanca, Spain; 7Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; and 8Servicio de Hematología, Hospital Universitario de Salamanca, Salamanca, Spain
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Persistent expansions of CD4+ CD8+ peripheral blood T cells.
CD4+ CD8+ cells are present during T cell differentiation in the thymus. Less than 2% of normal T cells that coexpress CD4 and CD8 also are released in the circulation and are present in the peripheral blood. In this study, nine individuals are described that manifested persistent expansions (11% to 43%) of circulating CD4+ CD8+ T cells that in three cases had large granular lymphocyte (LGL) mo...
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